Vitamin B-3 Treatment: Safe and Beneficial
Then, the researchers conducted four human studies to examine whether quinolinate can be used to indicate reduced NAD+ biosynthesis.
They discovered that the patients who had undergone major surgery and were therefore prone to developing acute kidney injury had high levels of quinolinate in their urine.
Also, the researchers administered large doses of vitamin B-3 to 41 people who had undergone cardiac surgery.
“Our results,” explains study co-author Dr. Kamal Khabbaz, the chief of cardiac surgery at the CardioVascular Institute at the BIDMC, “suggest that NAD+ biosynthesis becomes impaired during human acute kidney injury and that augmenting vitamin B-3 levels may be safe and potentially beneficial to patients.”
“What’s more,” continues Dr. Khabbaz, “we showed that urinary measurements in at-risk patients can indicate this impairment and, furthermore, predict adverse outcomes.”
“Restoring NAD+ could constitute an important advance for patients at risk for acute kidney injury, though further studies are needed to verify these findings,” concludes Dr. Khabbaz.
Dr. Parikh echoes the same caution, saying, “These findings are very early, but the results suggest that we could one day have a non-invasive test for NAD+ status and perhaps even treat acute kidney injury by boosting NAD+ levels.”
“We were able to detect a drop in NAD+ in the urine of high-risk patients who were either in an intensive care unit or undergoing a major surgery and found that oral vitamin B-3 could safely elevate NAD+ in high-risk patients.” – Dr. Samir M. Parikh